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2021年12月9日，據(jù)歐盟食品安全局（EFSA）消息,，應歐盟委員會要求,，歐盟動物飼料添加劑和產品（FEEDAP）研究小組就谷氨酸棒桿菌KCCM 80185生產的L-異亮氨酸（l-isoleucine）作為所有動物飼料添加劑的安全性和有效性發(fā)表科學意見,。

經(jīng)過評估，專家小組認為在擬議的使用條件下,，該添加劑對目標物種,、消費者和環(huán)境是安全的。評估中的添加劑被認為是非反芻動物物種氨基酸L-異亮氨酸的有效來源,。為了使補充的L-異亮氨酸對反芻動物和非反芻動物同樣有效,，需要防止其在瘤胃中降解。

部分原文報道如下：

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of a feed additive consisting of l-isoleucine produced by Corynebacterium glutamicum KCCM 80185 when used as a nutritional additive in feed and water for drinking for all animal species. The production strain is genetically modified, does not carry acquired antimicrobial resistance genes and no viable cells of the production strain were detected in the final product. The FEEDAP Panel could not exclude the presence of recombinant DNA from the production strain in the product. However, since no sequences of concern remain in the final production strain, the potential presence of recombinant DNA in the final product does not raise any safety concerns. The Panel concluded that the additive is safe for the target species, for the consumer and for the environment under the proposed conditions of use. Regarding the use in water, the FEEDAP Panel reiterated its concerns over the safety of l-isoleucine administered simultaneously via water for drinking and feed owing to the risk of nutritional imbalances and hygienic reasons. The FEEDAP Panel concluded that l-isoleucine produced by C. glutamicum KCCM 80185 is considered not toxic by inhalation, not irritant to skin or eyes and not a dermal sensitiser. However, due to the high dusting potential, exposure to dust per se might be a hazard for the user. l-Isoleucine produced by C. glutamicum KCCM 80185 is considered as an efficacious source of the essential amino acid l-isoleucine for non-ruminant animal species. For the supplemental l-isoleucine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.